Issues in the management of simple and complex meconium ileus

Protein in meconium from meconium ileus.

Meconium ileus is the earliest manifestation of cystic fibrosis, and several investigations have been undertaken to determine its cause. In 1952, Buchanan and Rapoport showed that the ash content of abnormal meconium was twice as high as that ofnormal newborns, and that whereas normal meconium consisted of only 7% protein, this rose to 85% in meconium ileus. We here show that the proteins conce...

Pediatric Meconium Ileus

Pediatric Meconium Ileus

Pediatric Meconium Ileus

Isolated Meconium Ileus

Isolated meconium ileus as such is relatively rare. Two neonates presented with features of intestinal obstruction. On exploration, features of meconium were present. Temporary ileostomy with postoperative distal washes and medical management was done, followed by ileostomy closure at 6 months of life. Workup for cystic fibrosis and associated anomalies was negative. Both are thriving well at o...